PittsburghV1, Main, Exploration, bibRecord, 000A46

Two rare AKAP9 variants are associated with Alzheimer disease in African Americans

Identifieur interne : 000A46 ( Main/Exploration ); précédent : 000A45; suivant : 000A47

Two rare AKAP9 variants are associated with Alzheimer disease in African Americans

Auteurs : Mark W. Logue [États-Unis] ; Matthew Schu [États-Unis] ; Badri N. Vardarajan [États-Unis] ; John Farrell [États-Unis] ; David A. Bennett [États-Unis] ; Joseph D. Buxbaum [États-Unis] ; Goldie S. Byrd [États-Unis] ; Nilufer Ertekin-Taner [États-Unis] ; Denis Evans [États-Unis] ; Tatiana Foroud [États-Unis] ; Alison Goate [États-Unis] ; Neill R. Graff-Radford [États-Unis] ; M. Ilyas Kamboh [États-Unis] ; Walter A. Kukull [États-Unis] ; Jennifer J. Manly [États-Unis] ; Jonathan L. Haines [États-Unis] ; Richard Mayeux [États-Unis] ; Margaret A. Pericak-Vance [États-Unis] ; Gerard D. Schellenberg [États-Unis] ; Kathryn L. Lunetta [États-Unis] ; Clinton T. Baldwin [États-Unis] ; M. Daniele Fallin [États-Unis] ; Lindsay A. Farrer [États-Unis]

Source :

Alzheimer's & dementia : the journal of the Alzheimer's Association [ 1552-5260 ] ; 2014.

RBID : PMC:4253055

Descripteurs français

English descriptors

KwdEn :
- A Kinase Anchor Proteins (genetics), African Americans (genetics), Aged, Aged, 80 and over, Alzheimer Disease (ethnology), Alzheimer Disease (genetics), Cluster Analysis, Cytoskeletal Proteins (genetics), Female, Genetic Predisposition to Disease (genetics), Genome-Wide Association Study, Genotype, Humans, Linkage Disequilibrium, Male, Polymorphism, Single Nucleotide (genetics).
MESH :
- chemical , genetics : A Kinase Anchor Proteins, Cytoskeletal Proteins.
- ethnology : Alzheimer Disease.
- genetics : African Americans, Alzheimer Disease, Genetic Predisposition to Disease, Polymorphism, Single Nucleotide.
- Aged, Aged, 80 and over, Cluster Analysis, Female, Genome-Wide Association Study, Genotype, Humans, Linkage Disequilibrium, Male.

Abstract

Background

Less is known about the genetic basis of Alzheimer disease (AD) in African Americans (AAs) than in non-Hispanic whites.

Methods

Whole exome sequencing (WES) was performed on seven AA AD cases. Disease association with potentially AD-related variants from WES was assessed in an AA discovery cohort of 422 cases and 394 controls. Replication was sought in an AA sample of 1,037 cases and 1,869 controls from the Alzheimer Disease Genetics Consortium (ADGC).

Results

Forty-four SNPs from WES passed filtering criteria and were successfully genotyped, Nominally significant (p<0.05) association to AD was observed with two African-descent specific AKAP9 SNPs in tight linkage disequilibrium: rs144662445 (p=0.014) and rs149979685 (p=0.037). These associations were replicated in the ADGC sample (rs144662445: p=0.0022, odds ratio [OR]=2.75; rs149979685: p=0.0022, OR=3.61).

Conclusions

Because AKAP9 was not previously linked to AD risk, this study indicates a potential new disease mechanism.

Url:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4253055

DOI: 10.1016/j.jalz.2014.06.010
PubMed: 25172201
PubMed Central: 4253055

Affiliations:

Le document en format XML

<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Two rare <italic>AKAP9</italic> variants are associated with Alzheimer
disease in African Americans</title>
<author><name sortKey="Logue, Mark W" sort="Logue, Mark W" uniqKey="Logue M" first="Mark W." last="Logue">Mark W. Logue</name>
<affiliation wicri:level="2"><nlm:aff id="A1">Department of Medicine (Biomedical Genetics), Boston University Schools of Medicine and Public Health, Boston, MA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Massachusetts</region>
</placeName>
<wicri:cityArea>Department of Medicine (Biomedical Genetics), Boston University Schools of Medicine and Public Health, Boston</wicri:cityArea>
</affiliation>
<affiliation wicri:level="2"><nlm:aff id="A5">Department of Biostatistics, Boston University Schools of Medicine and Public Health, Boston, MA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Massachusetts</region>
</placeName>
<wicri:cityArea>Department of Biostatistics, Boston University Schools of Medicine and Public Health, Boston</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Schu, Matthew" sort="Schu, Matthew" uniqKey="Schu M" first="Matthew" last="Schu">Matthew Schu</name>
<affiliation wicri:level="2"><nlm:aff id="A1">Department of Medicine (Biomedical Genetics), Boston University Schools of Medicine and Public Health, Boston, MA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Massachusetts</region>
</placeName>
<wicri:cityArea>Department of Medicine (Biomedical Genetics), Boston University Schools of Medicine and Public Health, Boston</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Vardarajan, Badri N" sort="Vardarajan, Badri N" uniqKey="Vardarajan B" first="Badri N." last="Vardarajan">Badri N. Vardarajan</name>
<affiliation wicri:level="2"><nlm:aff id="A1">Department of Medicine (Biomedical Genetics), Boston University Schools of Medicine and Public Health, Boston, MA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Massachusetts</region>
</placeName>
<wicri:cityArea>Department of Medicine (Biomedical Genetics), Boston University Schools of Medicine and Public Health, Boston</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Farrell, John" sort="Farrell, John" uniqKey="Farrell J" first="John" last="Farrell">John Farrell</name>
<affiliation wicri:level="2"><nlm:aff id="A1">Department of Medicine (Biomedical Genetics), Boston University Schools of Medicine and Public Health, Boston, MA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Massachusetts</region>
</placeName>
<wicri:cityArea>Department of Medicine (Biomedical Genetics), Boston University Schools of Medicine and Public Health, Boston</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Bennett, David A" sort="Bennett, David A" uniqKey="Bennett D" first="David A." last="Bennett">David A. Bennett</name>
<affiliation wicri:level="2"><nlm:aff id="A6">Department of Rush Alzheimer’s Disease Center, Rush University Medical Center, Chicago, IL</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Illinois</region>
</placeName>
<wicri:cityArea>Department of Rush Alzheimer’s Disease Center, Rush University Medical Center, Chicago</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Buxbaum, Joseph D" sort="Buxbaum, Joseph D" uniqKey="Buxbaum J" first="Joseph D." last="Buxbaum">Joseph D. Buxbaum</name>
<affiliation wicri:level="2"><nlm:aff id="A7">Departments of Neuroscience and Genetics & Genomic Sciences, Mount Sinai School of Medicine, New York, NY</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">État de New York</region>
</placeName>
<wicri:cityArea>Departments of Neuroscience and Genetics & Genomic Sciences, Mount Sinai School of Medicine, New York</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Byrd, Goldie S" sort="Byrd, Goldie S" uniqKey="Byrd G" first="Goldie S." last="Byrd">Goldie S. Byrd</name>
<affiliation wicri:level="2"><nlm:aff id="A8">Department of Biology, North Carolina A & T State University, Greensboro, NC</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Caroline du Nord</region>
</placeName>
<wicri:cityArea>Department of Biology, North Carolina A & T State University, Greensboro</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Ertekin Taner, Nilufer" sort="Ertekin Taner, Nilufer" uniqKey="Ertekin Taner N" first="Nilufer" last="Ertekin-Taner">Nilufer Ertekin-Taner</name>
<affiliation wicri:level="2"><nlm:aff id="A9">Departments of Neuroscience and Neurology, Mayo Clinic, Jacksonville, FL</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Floride</region>
</placeName>
<wicri:cityArea>Departments of Neuroscience and Neurology, Mayo Clinic, Jacksonville</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Evans, Denis" sort="Evans, Denis" uniqKey="Evans D" first="Denis" last="Evans">Denis Evans</name>
<affiliation wicri:level="2"><nlm:aff id="A10">Rush Institute for Healthy Aging, Department of Internal Medicine, Rush University Medical Center, Chicago, IL</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Illinois</region>
</placeName>
<wicri:cityArea>Rush Institute for Healthy Aging, Department of Internal Medicine, Rush University Medical Center, Chicago</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Foroud, Tatiana" sort="Foroud, Tatiana" uniqKey="Foroud T" first="Tatiana" last="Foroud">Tatiana Foroud</name>
<affiliation wicri:level="2"><nlm:aff id="A11">Department of Medical and Molecular Genetics, Indiana University, Indianapolis, IN</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Indiana</region>
</placeName>
<wicri:cityArea>Department of Medical and Molecular Genetics, Indiana University, Indianapolis</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Goate, Alison" sort="Goate, Alison" uniqKey="Goate A" first="Alison" last="Goate">Alison Goate</name>
<affiliation wicri:level="2"><nlm:aff id="A12">Department of Psychiatry and Hope Center Program on Protein Aggregation and Neurodegeneration, Washington University School of Medicine, St. Louis, MI</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Michigan</region>
</placeName>
<wicri:cityArea>Department of Psychiatry and Hope Center Program on Protein Aggregation and Neurodegeneration, Washington University School of Medicine, St. Louis</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Graff Radford, Neill R" sort="Graff Radford, Neill R" uniqKey="Graff Radford N" first="Neill R." last="Graff-Radford">Neill R. Graff-Radford</name>
<affiliation wicri:level="2"><nlm:aff id="A9">Departments of Neuroscience and Neurology, Mayo Clinic, Jacksonville, FL</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Floride</region>
</placeName>
<wicri:cityArea>Departments of Neuroscience and Neurology, Mayo Clinic, Jacksonville</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Kamboh, M Ilyas" sort="Kamboh, M Ilyas" uniqKey="Kamboh M" first="M. Ilyas" last="Kamboh">M. Ilyas Kamboh</name>
<affiliation wicri:level="2"><nlm:aff id="A13">Department of Human Genetics and Alzheimer’s Disease Research Center, University of, Pittsburgh, Pittsburgh, PA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Pennsylvanie</region>
</placeName>
<wicri:cityArea>Department of Human Genetics and Alzheimer’s Disease Research Center, University of, Pittsburgh, Pittsburgh</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Kukull, Walter A" sort="Kukull, Walter A" uniqKey="Kukull W" first="Walter A." last="Kukull">Walter A. Kukull</name>
<affiliation wicri:level="2"><nlm:aff id="A14">National Alzheimer’s Coordinating Center and Department of Epidemiology, University of Washington, Seattle, WA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Washington (État)</region>
</placeName>
<wicri:cityArea>National Alzheimer’s Coordinating Center and Department of Epidemiology, University of Washington, Seattle</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Manly, Jennifer J" sort="Manly, Jennifer J" uniqKey="Manly J" first="Jennifer J." last="Manly">Jennifer J. Manly</name>
<affiliation wicri:level="2"><nlm:aff id="A15">Department of Neurology and the Taub Institute, Columbia University, New York, NY</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">État de New York</region>
</placeName>
<wicri:cityArea>Department of Neurology and the Taub Institute, Columbia University, New York</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Haines, Jonathan L" sort="Haines, Jonathan L" uniqKey="Haines J" first="Jonathan L." last="Haines">Jonathan L. Haines</name>
<affiliation wicri:level="2"><nlm:aff id="A16">Department of Epidemiology and Biostatistics, Case Western Reserve University, Cleveland, OH</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Ohio</region>
</placeName>
<wicri:cityArea>Department of Epidemiology and Biostatistics, Case Western Reserve University, Cleveland</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Mayeux, Richard" sort="Mayeux, Richard" uniqKey="Mayeux R" first="Richard" last="Mayeux">Richard Mayeux</name>
<affiliation wicri:level="2"><nlm:aff id="A15">Department of Neurology and the Taub Institute, Columbia University, New York, NY</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">État de New York</region>
</placeName>
<wicri:cityArea>Department of Neurology and the Taub Institute, Columbia University, New York</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Pericak Vance, Margaret A" sort="Pericak Vance, Margaret A" uniqKey="Pericak Vance M" first="Margaret A." last="Pericak-Vance">Margaret A. Pericak-Vance</name>
<affiliation wicri:level="2"><nlm:aff id="A17">The John P. Hussman Institute for Human Genomics, University of Miami, Miami, FL</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Floride</region>
</placeName>
<wicri:cityArea>The John P. Hussman Institute for Human Genomics, University of Miami, Miami</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Schellenberg, Gerard D" sort="Schellenberg, Gerard D" uniqKey="Schellenberg G" first="Gerard D." last="Schellenberg">Gerard D. Schellenberg</name>
<affiliation wicri:level="2"><nlm:aff id="A18">Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Pennsylvanie</region>
</placeName>
<wicri:cityArea>Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Lunetta, Kathryn L" sort="Lunetta, Kathryn L" uniqKey="Lunetta K" first="Kathryn L." last="Lunetta">Kathryn L. Lunetta</name>
<affiliation wicri:level="2"><nlm:aff id="A5">Department of Biostatistics, Boston University Schools of Medicine and Public Health, Boston, MA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Massachusetts</region>
</placeName>
<wicri:cityArea>Department of Biostatistics, Boston University Schools of Medicine and Public Health, Boston</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Baldwin, Clinton T" sort="Baldwin, Clinton T" uniqKey="Baldwin C" first="Clinton T." last="Baldwin">Clinton T. Baldwin</name>
<affiliation wicri:level="2"><nlm:aff id="A1">Department of Medicine (Biomedical Genetics), Boston University Schools of Medicine and Public Health, Boston, MA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Massachusetts</region>
</placeName>
<wicri:cityArea>Department of Medicine (Biomedical Genetics), Boston University Schools of Medicine and Public Health, Boston</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Fallin, M Daniele" sort="Fallin, M Daniele" uniqKey="Fallin M" first="M. Daniele" last="Fallin">M. Daniele Fallin</name>
<affiliation wicri:level="2"><nlm:aff id="A19">Department of Epidemiology, Johns Hopkins University School of Public Health, Baltimore, MD</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Maryland</region>
</placeName>
<wicri:cityArea>Department of Epidemiology, Johns Hopkins University School of Public Health, Baltimore</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Farrer, Lindsay A" sort="Farrer, Lindsay A" uniqKey="Farrer L" first="Lindsay A." last="Farrer">Lindsay A. Farrer</name>
<affiliation wicri:level="2"><nlm:aff id="A1">Department of Medicine (Biomedical Genetics), Boston University Schools of Medicine and Public Health, Boston, MA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Massachusetts</region>
</placeName>
<wicri:cityArea>Department of Medicine (Biomedical Genetics), Boston University Schools of Medicine and Public Health, Boston</wicri:cityArea>
</affiliation>
<affiliation wicri:level="2"><nlm:aff id="A2">Department of Neurology, Boston University Schools of Medicine and Public Health, Boston, MA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Massachusetts</region>
</placeName>
<wicri:cityArea>Department of Neurology, Boston University Schools of Medicine and Public Health, Boston</wicri:cityArea>
</affiliation>
<affiliation wicri:level="2"><nlm:aff id="A3">Department of Ophthalmology, Boston University Schools of Medicine and Public Health, Boston, MA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Massachusetts</region>
</placeName>
<wicri:cityArea>Department of Ophthalmology, Boston University Schools of Medicine and Public Health, Boston</wicri:cityArea>
</affiliation>
<affiliation wicri:level="2"><nlm:aff id="A4">Department of Epidemiology, and Boston University Schools of Medicine and Public Health, Boston, MA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Massachusetts</region>
</placeName>
<wicri:cityArea>Department of Epidemiology, and Boston University Schools of Medicine and Public Health, Boston</wicri:cityArea>
</affiliation>
<affiliation wicri:level="2"><nlm:aff id="A5">Department of Biostatistics, Boston University Schools of Medicine and Public Health, Boston, MA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Massachusetts</region>
</placeName>
<wicri:cityArea>Department of Biostatistics, Boston University Schools of Medicine and Public Health, Boston</wicri:cityArea>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PMC</idno>
<idno type="pmid">25172201</idno>
<idno type="pmc">4253055</idno>
<idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4253055</idno>
<idno type="RBID">PMC:4253055</idno>
<idno type="doi">10.1016/j.jalz.2014.06.010</idno>
<date when="2014">2014</date>
<idno type="wicri:Area/Pmc/Corpus">001080</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">001080</idno>
<idno type="wicri:Area/Pmc/Curation">001055</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">001055</idno>
<idno type="wicri:Area/Pmc/Checkpoint">000156</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">000156</idno>
<idno type="wicri:source">PubMed</idno>
<idno type="wicri:Area/PubMed/Corpus">001444</idno>
<idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">001444</idno>
<idno type="wicri:Area/PubMed/Curation">001438</idno>
<idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">001438</idno>
<idno type="wicri:Area/PubMed/Checkpoint">001438</idno>
<idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">001438</idno>
<idno type="wicri:Area/Ncbi/Merge">003252</idno>
<idno type="wicri:Area/Ncbi/Curation">003252</idno>
<idno type="wicri:Area/Ncbi/Checkpoint">003252</idno>
<idno type="wicri:Area/Main/Merge">000A54</idno>
<idno type="wicri:Area/Main/Curation">000A46</idno>
<idno type="wicri:Area/Main/Exploration">000A46</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Two rare <italic>AKAP9</italic> variants are associated with Alzheimer
disease in African Americans</title>
<author><name sortKey="Logue, Mark W" sort="Logue, Mark W" uniqKey="Logue M" first="Mark W." last="Logue">Mark W. Logue</name>
<affiliation wicri:level="2"><nlm:aff id="A1">Department of Medicine (Biomedical Genetics), Boston University Schools of Medicine and Public Health, Boston, MA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Massachusetts</region>
</placeName>
<wicri:cityArea>Department of Medicine (Biomedical Genetics), Boston University Schools of Medicine and Public Health, Boston</wicri:cityArea>
</affiliation>
<affiliation wicri:level="2"><nlm:aff id="A5">Department of Biostatistics, Boston University Schools of Medicine and Public Health, Boston, MA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Massachusetts</region>
</placeName>
<wicri:cityArea>Department of Biostatistics, Boston University Schools of Medicine and Public Health, Boston</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Schu, Matthew" sort="Schu, Matthew" uniqKey="Schu M" first="Matthew" last="Schu">Matthew Schu</name>
<affiliation wicri:level="2"><nlm:aff id="A1">Department of Medicine (Biomedical Genetics), Boston University Schools of Medicine and Public Health, Boston, MA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Massachusetts</region>
</placeName>
<wicri:cityArea>Department of Medicine (Biomedical Genetics), Boston University Schools of Medicine and Public Health, Boston</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Vardarajan, Badri N" sort="Vardarajan, Badri N" uniqKey="Vardarajan B" first="Badri N." last="Vardarajan">Badri N. Vardarajan</name>
<affiliation wicri:level="2"><nlm:aff id="A1">Department of Medicine (Biomedical Genetics), Boston University Schools of Medicine and Public Health, Boston, MA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Massachusetts</region>
</placeName>
<wicri:cityArea>Department of Medicine (Biomedical Genetics), Boston University Schools of Medicine and Public Health, Boston</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Farrell, John" sort="Farrell, John" uniqKey="Farrell J" first="John" last="Farrell">John Farrell</name>
<affiliation wicri:level="2"><nlm:aff id="A1">Department of Medicine (Biomedical Genetics), Boston University Schools of Medicine and Public Health, Boston, MA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Massachusetts</region>
</placeName>
<wicri:cityArea>Department of Medicine (Biomedical Genetics), Boston University Schools of Medicine and Public Health, Boston</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Bennett, David A" sort="Bennett, David A" uniqKey="Bennett D" first="David A." last="Bennett">David A. Bennett</name>
<affiliation wicri:level="2"><nlm:aff id="A6">Department of Rush Alzheimer’s Disease Center, Rush University Medical Center, Chicago, IL</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Illinois</region>
</placeName>
<wicri:cityArea>Department of Rush Alzheimer’s Disease Center, Rush University Medical Center, Chicago</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Buxbaum, Joseph D" sort="Buxbaum, Joseph D" uniqKey="Buxbaum J" first="Joseph D." last="Buxbaum">Joseph D. Buxbaum</name>
<affiliation wicri:level="2"><nlm:aff id="A7">Departments of Neuroscience and Genetics & Genomic Sciences, Mount Sinai School of Medicine, New York, NY</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">État de New York</region>
</placeName>
<wicri:cityArea>Departments of Neuroscience and Genetics & Genomic Sciences, Mount Sinai School of Medicine, New York</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Byrd, Goldie S" sort="Byrd, Goldie S" uniqKey="Byrd G" first="Goldie S." last="Byrd">Goldie S. Byrd</name>
<affiliation wicri:level="2"><nlm:aff id="A8">Department of Biology, North Carolina A & T State University, Greensboro, NC</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Caroline du Nord</region>
</placeName>
<wicri:cityArea>Department of Biology, North Carolina A & T State University, Greensboro</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Ertekin Taner, Nilufer" sort="Ertekin Taner, Nilufer" uniqKey="Ertekin Taner N" first="Nilufer" last="Ertekin-Taner">Nilufer Ertekin-Taner</name>
<affiliation wicri:level="2"><nlm:aff id="A9">Departments of Neuroscience and Neurology, Mayo Clinic, Jacksonville, FL</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Floride</region>
</placeName>
<wicri:cityArea>Departments of Neuroscience and Neurology, Mayo Clinic, Jacksonville</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Evans, Denis" sort="Evans, Denis" uniqKey="Evans D" first="Denis" last="Evans">Denis Evans</name>
<affiliation wicri:level="2"><nlm:aff id="A10">Rush Institute for Healthy Aging, Department of Internal Medicine, Rush University Medical Center, Chicago, IL</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Illinois</region>
</placeName>
<wicri:cityArea>Rush Institute for Healthy Aging, Department of Internal Medicine, Rush University Medical Center, Chicago</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Foroud, Tatiana" sort="Foroud, Tatiana" uniqKey="Foroud T" first="Tatiana" last="Foroud">Tatiana Foroud</name>
<affiliation wicri:level="2"><nlm:aff id="A11">Department of Medical and Molecular Genetics, Indiana University, Indianapolis, IN</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Indiana</region>
</placeName>
<wicri:cityArea>Department of Medical and Molecular Genetics, Indiana University, Indianapolis</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Goate, Alison" sort="Goate, Alison" uniqKey="Goate A" first="Alison" last="Goate">Alison Goate</name>
<affiliation wicri:level="2"><nlm:aff id="A12">Department of Psychiatry and Hope Center Program on Protein Aggregation and Neurodegeneration, Washington University School of Medicine, St. Louis, MI</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Michigan</region>
</placeName>
<wicri:cityArea>Department of Psychiatry and Hope Center Program on Protein Aggregation and Neurodegeneration, Washington University School of Medicine, St. Louis</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Graff Radford, Neill R" sort="Graff Radford, Neill R" uniqKey="Graff Radford N" first="Neill R." last="Graff-Radford">Neill R. Graff-Radford</name>
<affiliation wicri:level="2"><nlm:aff id="A9">Departments of Neuroscience and Neurology, Mayo Clinic, Jacksonville, FL</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Floride</region>
</placeName>
<wicri:cityArea>Departments of Neuroscience and Neurology, Mayo Clinic, Jacksonville</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Kamboh, M Ilyas" sort="Kamboh, M Ilyas" uniqKey="Kamboh M" first="M. Ilyas" last="Kamboh">M. Ilyas Kamboh</name>
<affiliation wicri:level="2"><nlm:aff id="A13">Department of Human Genetics and Alzheimer’s Disease Research Center, University of, Pittsburgh, Pittsburgh, PA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Pennsylvanie</region>
</placeName>
<wicri:cityArea>Department of Human Genetics and Alzheimer’s Disease Research Center, University of, Pittsburgh, Pittsburgh</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Kukull, Walter A" sort="Kukull, Walter A" uniqKey="Kukull W" first="Walter A." last="Kukull">Walter A. Kukull</name>
<affiliation wicri:level="2"><nlm:aff id="A14">National Alzheimer’s Coordinating Center and Department of Epidemiology, University of Washington, Seattle, WA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Washington (État)</region>
</placeName>
<wicri:cityArea>National Alzheimer’s Coordinating Center and Department of Epidemiology, University of Washington, Seattle</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Manly, Jennifer J" sort="Manly, Jennifer J" uniqKey="Manly J" first="Jennifer J." last="Manly">Jennifer J. Manly</name>
<affiliation wicri:level="2"><nlm:aff id="A15">Department of Neurology and the Taub Institute, Columbia University, New York, NY</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">État de New York</region>
</placeName>
<wicri:cityArea>Department of Neurology and the Taub Institute, Columbia University, New York</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Haines, Jonathan L" sort="Haines, Jonathan L" uniqKey="Haines J" first="Jonathan L." last="Haines">Jonathan L. Haines</name>
<affiliation wicri:level="2"><nlm:aff id="A16">Department of Epidemiology and Biostatistics, Case Western Reserve University, Cleveland, OH</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Ohio</region>
</placeName>
<wicri:cityArea>Department of Epidemiology and Biostatistics, Case Western Reserve University, Cleveland</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Mayeux, Richard" sort="Mayeux, Richard" uniqKey="Mayeux R" first="Richard" last="Mayeux">Richard Mayeux</name>
<affiliation wicri:level="2"><nlm:aff id="A15">Department of Neurology and the Taub Institute, Columbia University, New York, NY</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">État de New York</region>
</placeName>
<wicri:cityArea>Department of Neurology and the Taub Institute, Columbia University, New York</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Pericak Vance, Margaret A" sort="Pericak Vance, Margaret A" uniqKey="Pericak Vance M" first="Margaret A." last="Pericak-Vance">Margaret A. Pericak-Vance</name>
<affiliation wicri:level="2"><nlm:aff id="A17">The John P. Hussman Institute for Human Genomics, University of Miami, Miami, FL</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Floride</region>
</placeName>
<wicri:cityArea>The John P. Hussman Institute for Human Genomics, University of Miami, Miami</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Schellenberg, Gerard D" sort="Schellenberg, Gerard D" uniqKey="Schellenberg G" first="Gerard D." last="Schellenberg">Gerard D. Schellenberg</name>
<affiliation wicri:level="2"><nlm:aff id="A18">Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Pennsylvanie</region>
</placeName>
<wicri:cityArea>Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Lunetta, Kathryn L" sort="Lunetta, Kathryn L" uniqKey="Lunetta K" first="Kathryn L." last="Lunetta">Kathryn L. Lunetta</name>
<affiliation wicri:level="2"><nlm:aff id="A5">Department of Biostatistics, Boston University Schools of Medicine and Public Health, Boston, MA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Massachusetts</region>
</placeName>
<wicri:cityArea>Department of Biostatistics, Boston University Schools of Medicine and Public Health, Boston</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Baldwin, Clinton T" sort="Baldwin, Clinton T" uniqKey="Baldwin C" first="Clinton T." last="Baldwin">Clinton T. Baldwin</name>
<affiliation wicri:level="2"><nlm:aff id="A1">Department of Medicine (Biomedical Genetics), Boston University Schools of Medicine and Public Health, Boston, MA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Massachusetts</region>
</placeName>
<wicri:cityArea>Department of Medicine (Biomedical Genetics), Boston University Schools of Medicine and Public Health, Boston</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Fallin, M Daniele" sort="Fallin, M Daniele" uniqKey="Fallin M" first="M. Daniele" last="Fallin">M. Daniele Fallin</name>
<affiliation wicri:level="2"><nlm:aff id="A19">Department of Epidemiology, Johns Hopkins University School of Public Health, Baltimore, MD</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Maryland</region>
</placeName>
<wicri:cityArea>Department of Epidemiology, Johns Hopkins University School of Public Health, Baltimore</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Farrer, Lindsay A" sort="Farrer, Lindsay A" uniqKey="Farrer L" first="Lindsay A." last="Farrer">Lindsay A. Farrer</name>
<affiliation wicri:level="2"><nlm:aff id="A1">Department of Medicine (Biomedical Genetics), Boston University Schools of Medicine and Public Health, Boston, MA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Massachusetts</region>
</placeName>
<wicri:cityArea>Department of Medicine (Biomedical Genetics), Boston University Schools of Medicine and Public Health, Boston</wicri:cityArea>
</affiliation>
<affiliation wicri:level="2"><nlm:aff id="A2">Department of Neurology, Boston University Schools of Medicine and Public Health, Boston, MA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Massachusetts</region>
</placeName>
<wicri:cityArea>Department of Neurology, Boston University Schools of Medicine and Public Health, Boston</wicri:cityArea>
</affiliation>
<affiliation wicri:level="2"><nlm:aff id="A3">Department of Ophthalmology, Boston University Schools of Medicine and Public Health, Boston, MA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Massachusetts</region>
</placeName>
<wicri:cityArea>Department of Ophthalmology, Boston University Schools of Medicine and Public Health, Boston</wicri:cityArea>
</affiliation>
<affiliation wicri:level="2"><nlm:aff id="A4">Department of Epidemiology, and Boston University Schools of Medicine and Public Health, Boston, MA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Massachusetts</region>
</placeName>
<wicri:cityArea>Department of Epidemiology, and Boston University Schools of Medicine and Public Health, Boston</wicri:cityArea>
</affiliation>
<affiliation wicri:level="2"><nlm:aff id="A5">Department of Biostatistics, Boston University Schools of Medicine and Public Health, Boston, MA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Massachusetts</region>
</placeName>
<wicri:cityArea>Department of Biostatistics, Boston University Schools of Medicine and Public Health, Boston</wicri:cityArea>
</affiliation>
</author>
</analytic>
<series><title level="j">Alzheimer's & dementia : the journal of the Alzheimer's Association</title>
<idno type="ISSN">1552-5260</idno>
<idno type="eISSN">1552-5279</idno>
<imprint><date when="2014">2014</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>A Kinase Anchor Proteins (genetics)</term>
<term>African Americans (genetics)</term>
<term>Aged</term>
<term>Aged, 80 and over</term>
<term>Alzheimer Disease (ethnology)</term>
<term>Alzheimer Disease (genetics)</term>
<term>Cluster Analysis</term>
<term>Cytoskeletal Proteins (genetics)</term>
<term>Female</term>
<term>Genetic Predisposition to Disease (genetics)</term>
<term>Genome-Wide Association Study</term>
<term>Genotype</term>
<term>Humans</term>
<term>Linkage Disequilibrium</term>
<term>Male</term>
<term>Polymorphism, Single Nucleotide (genetics)</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>Afro-Américains (génétique)</term>
<term>Analyse de regroupements</term>
<term>Déséquilibre de liaison</term>
<term>Femelle</term>
<term>Génotype</term>
<term>Humains</term>
<term>Maladie d'Alzheimer (ethnologie)</term>
<term>Maladie d'Alzheimer (génétique)</term>
<term>Mâle</term>
<term>Polymorphisme de nucléotide simple (génétique)</term>
<term>Protéines d'ancrage aux protéines kinases A (génétique)</term>
<term>Protéines du cytosquelette (génétique)</term>
<term>Prédisposition génétique à une maladie (génétique)</term>
<term>Sujet âgé</term>
<term>Sujet âgé de 80 ans ou plus</term>
<term>Étude d'association pangénomique</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>A Kinase Anchor Proteins</term>
<term>Cytoskeletal Proteins</term>
</keywords>
<keywords scheme="MESH" qualifier="ethnologie" xml:lang="fr"><term>Maladie d'Alzheimer</term>
</keywords>
<keywords scheme="MESH" qualifier="ethnology" xml:lang="en"><term>Alzheimer Disease</term>
</keywords>
<keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>African Americans</term>
<term>Alzheimer Disease</term>
<term>Genetic Predisposition to Disease</term>
<term>Polymorphism, Single Nucleotide</term>
</keywords>
<keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Afro-Américains</term>
<term>Maladie d'Alzheimer</term>
<term>Polymorphisme de nucléotide simple</term>
<term>Protéines d'ancrage aux protéines kinases A</term>
<term>Protéines du cytosquelette</term>
<term>Prédisposition génétique à une maladie</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Aged</term>
<term>Aged, 80 and over</term>
<term>Cluster Analysis</term>
<term>Female</term>
<term>Genome-Wide Association Study</term>
<term>Genotype</term>
<term>Humans</term>
<term>Linkage Disequilibrium</term>
<term>Male</term>
</keywords>
<keywords scheme="MESH" xml:lang="fr"><term>Analyse de regroupements</term>
<term>Déséquilibre de liaison</term>
<term>Femelle</term>
<term>Génotype</term>
<term>Humains</term>
<term>Mâle</term>
<term>Sujet âgé</term>
<term>Sujet âgé de 80 ans ou plus</term>
<term>Étude d'association pangénomique</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en"><sec id="S1"><title>Background</title>
<p id="P3">Less is known about the genetic basis of Alzheimer disease (AD) in African
Americans (AAs) than in non-Hispanic whites.</p>
</sec>
<sec id="S2"><title>Methods</title>
<p id="P4">Whole exome sequencing (WES) was performed on seven AA AD cases. Disease
association with potentially AD-related variants from WES was assessed in an AA
discovery cohort of 422 cases and 394 controls. Replication was sought in an AA sample
of 1,037 cases and 1,869 controls from the Alzheimer Disease Genetics Consortium
(ADGC).</p>
</sec>
<sec id="S3"><title>Results</title>
<p id="P5">Forty-four SNPs from WES passed filtering criteria and were successfully
genotyped, Nominally significant (p<0.05) association to AD was observed with
two African-descent specific <italic>AKAP9</italic> SNPs in tight linkage
disequilibrium: rs144662445 (p=0.014) and rs149979685 (p=0.037). These associations were
replicated in the ADGC sample (rs144662445: p=0.0022, odds ratio [OR]=2.75; rs149979685:
p=0.0022, OR=3.61).</p>
</sec>
<sec id="S4"><title>Conclusions</title>
<p id="P6">Because <italic>AKAP9</italic> was not previously linked to AD risk, this study
indicates a potential new disease mechanism.</p>
</sec>
</div>
</front>
</TEI>
<affiliations><list><country><li>États-Unis</li>
</country>
<region><li>Caroline du Nord</li>
<li>Floride</li>
<li>Illinois</li>
<li>Indiana</li>
<li>Maryland</li>
<li>Massachusetts</li>
<li>Michigan</li>
<li>Ohio</li>
<li>Pennsylvanie</li>
<li>Washington (État)</li>
<li>État de New York</li>
</region>
</list>
<tree><country name="États-Unis"><region name="Massachusetts"><name sortKey="Logue, Mark W" sort="Logue, Mark W" uniqKey="Logue M" first="Mark W." last="Logue">Mark W. Logue</name>
</region>
<name sortKey="Baldwin, Clinton T" sort="Baldwin, Clinton T" uniqKey="Baldwin C" first="Clinton T." last="Baldwin">Clinton T. Baldwin</name>
<name sortKey="Bennett, David A" sort="Bennett, David A" uniqKey="Bennett D" first="David A." last="Bennett">David A. Bennett</name>
<name sortKey="Buxbaum, Joseph D" sort="Buxbaum, Joseph D" uniqKey="Buxbaum J" first="Joseph D." last="Buxbaum">Joseph D. Buxbaum</name>
<name sortKey="Byrd, Goldie S" sort="Byrd, Goldie S" uniqKey="Byrd G" first="Goldie S." last="Byrd">Goldie S. Byrd</name>
<name sortKey="Ertekin Taner, Nilufer" sort="Ertekin Taner, Nilufer" uniqKey="Ertekin Taner N" first="Nilufer" last="Ertekin-Taner">Nilufer Ertekin-Taner</name>
<name sortKey="Evans, Denis" sort="Evans, Denis" uniqKey="Evans D" first="Denis" last="Evans">Denis Evans</name>
<name sortKey="Fallin, M Daniele" sort="Fallin, M Daniele" uniqKey="Fallin M" first="M. Daniele" last="Fallin">M. Daniele Fallin</name>
<name sortKey="Farrell, John" sort="Farrell, John" uniqKey="Farrell J" first="John" last="Farrell">John Farrell</name>
<name sortKey="Farrer, Lindsay A" sort="Farrer, Lindsay A" uniqKey="Farrer L" first="Lindsay A." last="Farrer">Lindsay A. Farrer</name>
<name sortKey="Farrer, Lindsay A" sort="Farrer, Lindsay A" uniqKey="Farrer L" first="Lindsay A." last="Farrer">Lindsay A. Farrer</name>
<name sortKey="Farrer, Lindsay A" sort="Farrer, Lindsay A" uniqKey="Farrer L" first="Lindsay A." last="Farrer">Lindsay A. Farrer</name>
<name sortKey="Farrer, Lindsay A" sort="Farrer, Lindsay A" uniqKey="Farrer L" first="Lindsay A." last="Farrer">Lindsay A. Farrer</name>
<name sortKey="Farrer, Lindsay A" sort="Farrer, Lindsay A" uniqKey="Farrer L" first="Lindsay A." last="Farrer">Lindsay A. Farrer</name>
<name sortKey="Foroud, Tatiana" sort="Foroud, Tatiana" uniqKey="Foroud T" first="Tatiana" last="Foroud">Tatiana Foroud</name>
<name sortKey="Goate, Alison" sort="Goate, Alison" uniqKey="Goate A" first="Alison" last="Goate">Alison Goate</name>
<name sortKey="Graff Radford, Neill R" sort="Graff Radford, Neill R" uniqKey="Graff Radford N" first="Neill R." last="Graff-Radford">Neill R. Graff-Radford</name>
<name sortKey="Haines, Jonathan L" sort="Haines, Jonathan L" uniqKey="Haines J" first="Jonathan L." last="Haines">Jonathan L. Haines</name>
<name sortKey="Kamboh, M Ilyas" sort="Kamboh, M Ilyas" uniqKey="Kamboh M" first="M. Ilyas" last="Kamboh">M. Ilyas Kamboh</name>
<name sortKey="Kukull, Walter A" sort="Kukull, Walter A" uniqKey="Kukull W" first="Walter A." last="Kukull">Walter A. Kukull</name>
<name sortKey="Logue, Mark W" sort="Logue, Mark W" uniqKey="Logue M" first="Mark W." last="Logue">Mark W. Logue</name>
<name sortKey="Lunetta, Kathryn L" sort="Lunetta, Kathryn L" uniqKey="Lunetta K" first="Kathryn L." last="Lunetta">Kathryn L. Lunetta</name>
<name sortKey="Manly, Jennifer J" sort="Manly, Jennifer J" uniqKey="Manly J" first="Jennifer J." last="Manly">Jennifer J. Manly</name>
<name sortKey="Mayeux, Richard" sort="Mayeux, Richard" uniqKey="Mayeux R" first="Richard" last="Mayeux">Richard Mayeux</name>
<name sortKey="Pericak Vance, Margaret A" sort="Pericak Vance, Margaret A" uniqKey="Pericak Vance M" first="Margaret A." last="Pericak-Vance">Margaret A. Pericak-Vance</name>
<name sortKey="Schellenberg, Gerard D" sort="Schellenberg, Gerard D" uniqKey="Schellenberg G" first="Gerard D." last="Schellenberg">Gerard D. Schellenberg</name>
<name sortKey="Schu, Matthew" sort="Schu, Matthew" uniqKey="Schu M" first="Matthew" last="Schu">Matthew Schu</name>
<name sortKey="Vardarajan, Badri N" sort="Vardarajan, Badri N" uniqKey="Vardarajan B" first="Badri N." last="Vardarajan">Badri N. Vardarajan</name>
</country>
</tree>
</affiliations>
</record>

Pour manipuler ce document sous Unix (Dilib)

EXPLOR_STEP=$WICRI_ROOT/Wicri/Amérique/explor/PittsburghV1/Data/Main/Exploration

HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000A46 | SxmlIndent | more

HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 000A46 | SxmlIndent | more

Pour mettre un lien sur cette page dans le réseau Wicri

{{Explor lien
   |wiki=    Wicri/Amérique
   |area=    PittsburghV1
   |flux=    Main
   |étape=   Exploration
   |type=    RBID
   |clé=     PMC:4253055
   |texte=   Two rare AKAP9 variants are associated with Alzheimer
disease in African Americans
}}

Pour générer des pages wiki

HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Exploration/RBID.i   -Sk "pubmed:25172201" \
       | HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd   \
       | NlmPubMed2Wicri -a PittsburghV1

This area was generated with Dilib version V0.6.38.
Data generation: Fri Jun 18 17:37:45 2021. Site generation: Fri Jun 18 18:15:47 2021

Serveur d'exploration sur Pittsburgh

Two rare AKAP9 variants are associated with Alzheimer disease in African Americans

Two rare AKAP9 variants are associated with Alzheimer disease in African Americans

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

Pour générer des pages wiki

	Serveur d'exploration sur Pittsburgh
	Attention, ce site est en cours de développement ! Attention, site généré par des moyens informatiques à partir de corpus bruts. Les informations ne sont donc pas validées.